Kills fleas within 12 hours of application. At 40% of the minimum recommended topical dose, 4 of the dogs experienced neurological signs indicative of avermectin toxicity including depression, ataxia, mydriasis, salivation, muscle fasciculation, and coma, and were euthanized. If you choose to bathe your dog in between treatments, we recommend use of a general grooming shampoo for pets. Place the tip of the tube on the skin between your dog's shoulder blades and gently squeeze to expel the solution on their skin. 5. Shampooing 90 minutes after treatment does not reduce the effectiveness of Advantage Multi for Dogs in the prevention of heartworm disease. How do I store and dispose of Advantage® II? more severe and may include coma and death. Top questions about Advantage® II for Dogs, Unlike chewable forms of flea prevention, Advantage, There is no expiration date required on the packaging by the EPA for Advantage. For consumer questions call 1-800-255-6826. Available for Android and iOS devices. P.O. The signs in this dog may have been related to peak serum levels of moxidectin, which vary between dogs, and occur between 1 and 21 days after application of Advantage Multi for Dogs. 2. Yes. Field Studies: Following treatment with Advantage Multifor Dogs or an active control, dog owners reported the following post-treatment reactions: During a field study using 61 dogs with pre-existing flea allergy dermatitis, one (1.6%) dog experienced localized pruritus immediately after imidacloprid application, and one investigator noted hyperkeratosis at the application site of one dog (1.6%). Heartworm Prevention: For prevention of heartworm disease, Advantage Multi for Dogs should be administered at one-month intervals. ADVANTAGE AND ADVANTAGE II DOSAGE CHART. How long does Advantage® II for dogs take to work? Prior to administration of Advantage Multi for Dogs, dogs should be tested for existing heartworm infection. (See WARNINGS.). Increased RBC, hemoglobin, activated partial thromboplastin, and direct bilirubin were observed in the treated group. For more detailed instructions, watch our application video. The following clinical observations also occurred in laboratory effectiveness studies following application with Advantage Multi for Dogs and may be directly attributed to the drug or may be secondary to the intestinal parasite burden or other underlying conditions in the dogs: diarrhea, bloody stools, vomiting, anorexia, lethargy, coughing, ocular discharge and nasal discharge. The tablet is beef flavored so your dog should readily accept it as a treat. The Material Safety Data Sheet (MSDS) provides additional occupational safety information. Puppies younger than 7 weeks of age and pregnant dogs should not use Advantage. Advantage Multi ® for Cats and Dogs does have an expiration date that can be found on the bottom edge of the package. Re-infesting or new fleas are killed within two hours for the remainder of the month. (Oh, I set off flea bombs too, and got us all out of here, for a day) So, when can I bathe them with for fleas--OR do I not need to, even though they … Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. HOW LONG DOES A DOSE LAST? Bayer, the Bayer Cross and Advantage Multi are registered trademarks of Bayer. Do not dispense dose applicator tubes without complete safety and administration information. If you choose to bathe your dog in between treatments, we recommend use of a general grooming shampoo for pets. Advantage® II for dogs combines two active ingredients: This combination plays a crucial role in treating and preventing infestations, because: Advantage® II flea prevention is applied to your dog topically, spreading over the skin and hair. How Long Does Collagen Supplements Take to Work? CAUTION: Federal (U.S.A.) law restricts Advantage Multi ® for Dogs to use by or on the order of a licensed veterinarian.. (Advantage Multi) Common Drug Name Imidacloprid plus moxidectin Common Brand Names Advantage Multi for Cats Advantage Multi for Dogs Note: Advantage Multi for Cats (in the 0.4 mL size only) has now been approved by FDA for some uses in ferrets. Just make sure your dog is dry before application. While the number of circulating microfilariae may decrease following treatment, Advantage Multi for Dogs is not effective for microfilariae clearance. Advantage® II for dogs kills fleas on dogs within 12 hours of application. If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. (See CONTRAINDICATIONS.). Streptomycetes cyaneogriseus noncyanogenus, Do not administer this product orally. The dog should be standing for application. Having and getting rid of fleas can be an unpleasant ordeal for both you and your cat. Well, I got the Advantage for them, and the flea pill, and they had them about 5 days ago. Remove one dose applicator tube (tube) from the package. Do not induce vomiting unless told to do so by the poison control center or physician. No, do not use Advantage® II for dogs on cats. If a dose is missed and a 30-day interval between doses is exceeded, administer AdvantageMulti for Dogs immediately and resume the monthly dosing schedule. The chemical name for imidacloprid is 1-[(6-Chloro-3- pyridinyl)methyl]-N-nitro-2-imidazolidinimine. (See ANIMAL SAFETY: – SafetyStudy in Heartworm-Positive Dogs.). Advantage Multi ® should not be used past its expiration date. Your dog is free to take a dip after Advantage® II has been on for 24 hours. With oral flea medications, fleas have to bite your dog and ingest the medication before they are killed. Can I touch my dog after applying Advantage® II for dogs? To further break down the Advantage … Lift the tube away from their skin, while maintaining pressure on the tube to make sure the product has all been squeezed out. Two puppies each in the 1X, 3X, and 5X groups had decreased appetites within 24 hours post-dosing. If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. If partly filled: Call your local solid waste agency for disposal instructions. body weight. The formula kills fleas within 24 hours and … Remove the tube from packaging and open it by putting the cap on the other end and twisting to break the seal. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. See the Product Label for specific application instructions by weight. Prevents and treats: Kills fleas at multiple life stages. Causes eye irritation. Observations at the application sites included damp, stiff or greasy hair, the appearance of a white deposit on the hair, and mild erythema, which resolved without treatment within 2 to 48 hours. Foreign Market Experience: Because the following events were reported voluntarily during post-approval use of the product in foreign markets, it is not always possible to reliably establish a causal relationship to drug exposure. Place in trash or offer for recycling if available. In a controlled, double-masked, field safety study, AdvantageMulti for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. Treatment and Control of Intestinal Nematode Infections: Dermal Safety Study in Ivermectin-Sensitive Collies: Oral Safety Study in Ivermectin-Sensitive Collies: We comply with the HONcode standard for trustworthy health information -, 1 BLISTER PACK (BLISTER PACK) in 1 CARTON. Advantage II for Cats kills fleas within 12 hours and reinfesting fleas within 2 hours. Select one or more newsletters to continue. The chemical name for moxidectin is [6R, 23E, 25S(E)]-5-O-Demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)- 6,28-epoxy-23-(methoxyimino) milbemycin B. There is no expiration date required on the packaging by the EPA for Advantage® II for dogs. Advantage Multi™ for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. For dogs weighing 20 lbs. The safe use of Advantage Multi for Dogs has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 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